Neurochemical biomarkers in the differential diagnosis of movement disorders
Identifieur interne : 002191 ( Main/Exploration ); précédent : 002190; suivant : 002192Neurochemical biomarkers in the differential diagnosis of movement disorders
Auteurs : Brit Mollenhauer [Allemagne] ; Claudia Trenkwalder [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-07-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Animals, Biological Markers (cerebrospinal fluid), Brain Chemistry, Cerebrospinal fluid, Diagnosis, Differential, Differential diagnostic, Humans, Movement Disorders (cerebrospinal fluid), Movement Disorders (diagnosis), Nerve Tissue Proteins (cerebrospinal fluid), Nerve Tissue Proteins (genetics), Nervous system diseases, biomarker, cerebrospinal fluid, movement disorder.
- MESH :
- chemical , cerebrospinal fluid : Biological Markers, Nerve Tissue Proteins.
- cerebrospinal fluid : Movement Disorders.
- diagnosis : Movement Disorders.
- chemical , genetics : Nerve Tissue Proteins.
- Animals, Brain Chemistry, Diagnosis, Differential, Humans.
Abstract
In recent years, the neurochemical analysis of neuronal proteins in cerebrospinal fluid (CSF) has become increasingly accepted for the diagnosis of neurodegenerative dementia diseases such as Alzheimer's disease and Creutzfeldt–Jakob disease. CSF surrounds the central nervous system, and in the composition of CSF proteins one finds brain‐specific proteins that are prioritized from blood‐derived proteins. Levels of specific CSF proteins could be very promising biomarkers for central nervous system diseases. We need the development of more easily accessible biomarkers, in the blood. In neurodegenerative diseases with and without dementia, studies on CSF and blood proteins have investigated the usefulness of biomarkers in differential diagnosis. The clinical diagnoses of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration still rely mainly on clinical symptoms as defined by international classification criteria. In this article, we review CSF biomarkers in these movement disorders and discuss recent published reports on the neurochemical intra vitam diagnosis of neurodegenerative disorders (including recent CSF α‐synuclein findings). © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22510
Affiliations:
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2009-07-30">2009-07-30</date><biblScope unit="vol">24</biblScope><biblScope unit="issue">10</biblScope><biblScope unit="page" from="1411">1411</biblScope><biblScope unit="page" to="1426">1426</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">936FFD6E48F6BC4176882F523E44B1F3A4DE505C</idno><idno type="DOI">10.1002/mds.22510</idno><idno type="ArticleID">MDS22510</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Biological Markers (cerebrospinal fluid)</term><term>Brain Chemistry</term><term>Cerebrospinal fluid</term><term>Diagnosis, Differential</term><term>Differential diagnostic</term><term>Humans</term><term>Movement Disorders (cerebrospinal fluid)</term><term>Movement Disorders (diagnosis)</term><term>Nerve Tissue Proteins (cerebrospinal fluid)</term><term>Nerve Tissue Proteins (genetics)</term><term>Nervous system diseases</term><term>biomarker</term><term>cerebrospinal fluid</term><term>movement disorder</term></keywords><keywords scheme="MESH" type="chemical" qualifier="cerebrospinal fluid" xml:lang="en"><term>Biological Markers</term><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" qualifier="cerebrospinal fluid" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Movement Disorders</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Nerve Tissue Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Brain Chemistry</term><term>Diagnosis, Differential</term><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Diagnostic différentiel</term><term>Liquide céphalorachidien</term><term>Pathologie du système nerveux</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In recent years, the neurochemical analysis of neuronal proteins in cerebrospinal fluid (CSF) has become increasingly accepted for the diagnosis of neurodegenerative dementia diseases such as Alzheimer's disease and Creutzfeldt–Jakob disease. 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In this article, we review CSF biomarkers in these movement disorders and discuss recent published reports on the neurochemical intra vitam diagnosis of neurodegenerative disorders (including recent CSF α‐synuclein findings). © 2009 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Kassel</li><li>Hesse (Land)</li></region><settlement><li>Cassel (Hesse)</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name></region><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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